Computational cancer biologist (omics) — CLL & Richter transformation
PhD candidate at the University of Turin (Functional Genomics Unit, Italy) in computational cancer biology.
My main track is chronic lymphocytic leukemia (CLL): I study how B-cell receptor (BCR) stereotyped subsets and NOTCH1 mutation status shape transcriptional and regulatory programs using multi-omics. In parallel, I work on Richter transformation (RT) - the aggressive lymphoma that can arise from CLL - as a separate line focused on cross-cohort signatures and actionable vulnerabilities.
What I’m working on now
- Main PhD (CLL): BCR stereotypy × NOTCH1 — multi-omics profiling of genotype-linked transcriptional/regulatory programs across IGHV4-34, IGHV1-69, and IGHV3-21 BCR stereotypes.
- Richter transformation (RT): cross-cohort genomics + transcriptomics to prioritize actionable vulnerabilities.
- Active collaborations: ongoing bulk RNA-seq analyses with CLL groups at IRCCS San Raffaele Hospital (HSR, Milan).
Selected highlights
- First-author manuscript (submitted): Common genomic and transcriptomic signatures in Richter transformation highlight druggable vulnerabilities and guide drug repurposing strategies. (Leukemia)
- Conference oral (selected): European School of Hematology (ESH), Vienna — March 2024 (Genomic and transcriptomic signatures in Richter transformation / drug repurposing).
- Teaching: BSc Biotechnology (Medical & Cancer Genetics; Epigenetics); MSc Medical Biotechnology (Biotech Therapies)
Education
- PhD, Medical Physiopathology (Computational Biology/Bioinformatics) — University of Turin — 2024–present (expected: Feb/March 2027)
- Master II (Omics Data Analysis) — University of Padua — 2023–2024 (completed during first PhD year)
- MSc, Molecular Biotechnology — University of Turin — 2021–2023
- BSc, Biomedical Biotechnology — University of Palermo — 2018–2021